Chronic inflammatory demyelinating polyneuropathy, or CIDP, is a rare, typically progressive autoimmune disease that involves nerve damage or dysfunction in the arms and legs. Damage to the covering of the nerves, called the myelin sheath, can disrupt the messages between the brain and various parts of the body, which can cause weakness and gradual loss of sensations and reflexes. Over time, this damage may lead to disability.1,2
The body’s immune system attacks the protective covering of the nerves, called the myelin sheath. Over time, the myelin sheath can be damaged, leaving the nerves exposed.1,2
The most common symptoms of CIDP are weakness, numbness, and tingling in the legs and arms. Other symptoms include fatigue, pain, balance issues, and impairment of the ability to walk. Some people have described feeling as if there were an electrical storm in their arms or legs.2
Symptoms usually occur on both sides of the body at the same time. But sometimes only one side is involved. People may experience symptoms in the arms, legs, or both. Symptoms may be recurrent, meaning they stop and start. They can also worsen over time.3
While there is no cure for CIDP, it can be treated. If you’ve been recently or newly diagnosed, treatment options for initial therapy typically include intravenous immune globulin (IVIG), corticosteroids, or plasma exchange (plasmapheresis). IVIG is one of the first treatments a doctor may recommend. The antibodies in IVIG help to block the immune and inflammatory processes that attack and destroy the nerve protective coating in adults with CIDP.1,2*
If CIDP is not treated, symptoms may get worse over time. People may experience worsening sensory symptoms, such as tingling and numbness. They may also experience weakness and loss of balance. Left untreated, CIDP can lead to permanent disability.1,2
Sometimes the symptoms of CIDP can resemble those of other diseases that impact the nervous system. These include MS (multiple sclerosis), ALS (amyotrophic lateral sclerosis), or GBS (Guillain-Barré syndrome). It can make CIDP challenging to diagnose. That’s why it’s so important to talk to your doctor about all the symptoms you may be experiencing.1,4,5
*The way in which IVIG works in treatment of patients with CIDP is not completely understood.

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References:
- Koski CL. CIDP: Chronic Inflammatory Demyelinating Polyneuropathy. Narberth, PA: GBS/CIDP Foundation International; 2012.
- Chronic inflammatory demyelinating polyradiculoneuropathy. University of Rochester Medical Center website. https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=134&ContentID=210. Accessed October 24, 2024.
- Gorson KC, Gooch CL. The (mis)diagnosis of CIDP: The high price of missing the mark. Neurology. 2015;85(6):488-489.
- Multiple sclerosis: symptoms and causes. Mayo Clinic website. http://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/dxc-20131884. Accessed October 24, 2024.
- Amyotrophic lateral sclerosis: symptoms and causes. Mayo Clinic. http://www.mayoclinic.org/diseases-conditions/amyotrophic-lateral-sclerosis/symptoms-causes/dxc-20247211?p=1. Accessed October 24, 2024.